Featured Publications
Get to know some of the latest publications by our faculties.
Estimating rare disease prevalence and costs in the USA: a cohort study approach using the Healthcare Cost Institute claims data
May 15, 2024
Estimating rare disease prevalence and costs in the USA: a cohort study approach using the Healthcare Cost Institute claims data
Orienting Ordered Scaffolds: Complexity and Algorithms
May 15, 2024
We address the problem of orientating ordered scaffolds as an optimization problem based on given weighted orientations of scaffolds and their pairs.
Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity
May 15, 2024
Bronchiolitis is a leading cause of infant hospitalizations but its immunopathology remains poorly understood.
Metabolite, protein, and tissue dysfunction associated with COVID‑19 disease severity
May 15, 2024
Proteins are direct products of the genome and metabolites are functional products of interactions between the host and other factors.
High-sensitivity pattern discovery in large, paired multiomic datasets
May 15, 2024
We present a novel framework which integrates hierarchical hypothesis testing with FDR correction to reveal linear and non-linear relationships among data.
Association of Early Aspirin Use With In-Hospital Mortality in Patients With Moderate COVID-19
May 15, 2024
Prior studies suggest aspirin may be associated with reduced mortality in high-risk patients with COVID-19, but patients with moderate COVID-19 are not studied.
546 Therapeutic beta-lactam dosages and broad-spectrum antibiotics are associated with short-term reductions in microbial richness and beta-diversity
May 15, 2024
People with cystic fibrosis have morbid pulmonary exacerbations. Antibiotics are common, yet the beta-lactam doses administered are less than half the time.
Host taxonomy determines the composition, structure, and diversity of the earthworm cast microbiome under homogenous feeding conditions
May 15, 2024
Host evolutionary history is a key factor shaping the earthworm cast microbiome, although its effect can be shadowed by the earthworm’s diet.
Induction of mastitis by cow-to-mouse fecal and milk microbiota transplantation causes microbiome dysbiosis and genomic functional perturbation in mice
May 15, 2024
To understand the host-tropism phenomena of bovine-tropic mastitis microbiomes, we developed a cow-to-mouse mastitis model.
Differential expression of single-cell RNA-seq data using Tweedie models
May 15, 2024
To model the technological variability in cross-platform scRNA-seq data, here we propose to use Tweedie generalized linear models.
Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis
May 15, 2024
We produced chromosome-level genome assemblies for A. coluzzii and A. arabiensis using Oxford Nanopore sequencing technology and Hi-C scaffolding approach.
Impact of Antibiotics on the Lung Microbiome and Lung Function in Children With Cystic Fibrosis 1 Year After Hospitalization for an Initial Pulmonary Exacerbation
May 15, 2024
The purpose of this study was to evaluate changes in the microbiome and lung function in people with CF over 1 year after an initial pulmonary exacerbation.