Dr. Keith Crandall, Director of the Computational Biology Institute at The George Washington University, will be participating in the Joint GW Children's National Informatics Seminar Series, on the subject of "Computational Approaches for Biodiversity Informatics".
DC CFAR Investigator, Amanda Castel, MD, MPH, and Marcos Perez-Losada, PhD, MS Receive NIH CFAR Administrative Supplement
CBI member Dr. Marcos Perez-Losada and his colleague Dr. Amanda Castel have received a NIH CFAR Administrative Supplement, concerning HIV transmission research in Washington, D.C.
The Computational Biology Institute is glad to welcome Alexander Ives as its new Administrative Associate, replacing Veronica Haight as she transitions out of her position.
Crandall Lab PhD student Jimmy Bernot will use his grant to conduct collborative research in London in 2017. Congratulations Jimmy!
Congratulations to Crandall Lab PhD student Jimmy Bernot for receiving the American Museum of National History (AMNH) Lerner Gray for Marine Research!
Reconstruction of Ancestral Genomes in Presence of Gene Gain and Loss
Burrowing Crayfish Species Mapped
Genetic Analysis Suggests Dwarf Crayfish Share Ancestor
Since most dramatic genomic changes are caused by genome rearrangements as well as gene duplications and gain/loss events, it becomes crucial to understand their mechanisms and reconstruct ancestral genomes of the given genomes.
In this study, researchers mapped the habitat and evolutionary lineage of burrowing crayfish by analyzing five genes in 19 species of Fallicambarus. The genus Fallicambarus consists entirely of primary burrowers-- crayfish that inhabit burrows for all of their lives. The burrows can have a negative impact when their habitat overlaps with human land-based activities such as farming. Because Fallicambarus is distinct from stream-based crayfish species, habitat shift may impact migration, speciation and conservation.
Though similar in appearance, researchers were unsure if Dwarf crayfish found in distinct locations along the Gulf Coast of United States and into Central México were members of a the same taxonomic genus. Analysis of samples collected at 59 locations support the hypothesis that the Gulf and Mexican Groups shared a common ancestor roughly 40 million years ago. It is likely that the Cambarellus genus became separate groups following changes in geographical barriers and climate, possibly related to the Eocene-Oligocene boundary.