An indepth reflection on where the field of Computational Biology was when PLOS Computational Biology started 10 years ago, and where the science is headed.
Director Keith Crandall highlights the benefits to having the CBI located at GW's Virginia Science and Technology Campus (VSTC) in Loudoun County, Virginia.
CBI Team Publishes Article Titled "Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma"
By Marcos Perez-Losada, Eduardo Castro-Nallar, Matthew Bendall, & Keith Crandall.
CBI Director Keith Crandall discusses what we still don't know about the effects of the Deepwater Horizon explosion on the Gulf, 5 years after it occured.
Congratulations to Alekseyev Lab members Shuai Jiang and Nikita Alexseev on each having a paper accepted to AlCob 2015.
A Genomic Approach to Pathogen Identification
Burrowing Crayfish Species Mapped
Genetic Analysis Suggests Dwarf Crayfish Share Ancestor
Review article authored by CBI researchers highlights the strengths and challenges associated with multi-locus sequence typing (MLST), a high-resolution genetic typing approach to identify species and strains of pathogens impacting human health, agriculture (animals and plants) and biosafety.
In this study, researchers mapped the habitat and evolutionary lineage of burrowing crayfish by analyzing five genes in 19 species of Fallicambarus. The genus Fallicambarus consists entirely of primary burrowers-- crayfish that inhabit burrows for all of their lives. The burrows can have a negative impact when their habitat overlaps with human land-based activities such as farming. Because Fallicambarus is distinct from stream-based crayfish species, habitat shift may impact migration, speciation and conservation.
Though similar in appearance, researchers were unsure if Dwarf crayfish found in distinct locations along the Gulf Coast of United States and into Central México were members of a the same taxonomic genus. Analysis of samples collected at 59 locations support the hypothesis that the Gulf and Mexican Groups shared a common ancestor roughly 40 million years ago. It is likely that the Cambarellus genus became separate groups following changes in geographical barriers and climate, possibly related to the Eocene-Oligocene boundary.