Tool Developed by Pavel Avdeyev Used in Recent Study in Nature

May 23, 2018

A recent study published in Nature, titled "Reconstruction of the diapsid ancestral genome permits chromosome evolution tracing in avian and non-avian dinosaurs," made use of a tool developed by Pavel Avdeyev, a graduate research assistant with the Computational Biology Institute. The tool, MGRA (Multiple Genome Rearrangements and Ancestors), allows for the reconstruction of ancestor genomes and evolutionary history of extant genomes. It takes as an input a set of genomes represented as sequences of genes, or synteny blocks, and produces such sequences for ancestral genomes as the internal nodes of the phylogenetic tree. The study applied the MGRA to determine the genomic structure of the diapsid common ancestor.