Keith Crandall and Marcos Perez-Losada Publish Article Concerning Seminal Simian Immunodeficiency Virus Origination from Multiple Genital Organs

July 05, 2018

Dr. Keith Crandall, Director of the Computational Biology Institute (CBI) and Professor in the Department of Epidemiology and Biostatistics (DEB), and Dr. Marcos Perez-Losada, member of the CBI Assistant Professor in DEB, co-authored an article, "Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs," published in the Journal of Virology on July 3rd, 2018. Working from an understanding that HIV is locally produced within the genital tract, the authors used single-genome amplification, amplicon sequencing and phylogenetic analyses to compare the genetic structures of simian immunodeficiency virus. The results of the study indicate that rather than originating from a single source, multiple genital organs are involved in the release of free virus and infected cells into semen. These findings have important implications for our understanding of systemic virus shedding and persistence in semen and for the design of eradication strategies to access viral reservoirs.