Jobs in Computational Biology

***POSTED 3/29/17***

Computational and Statistical Genomics Branch
National Human Genome Research Institute
National Institutes of Health

Postdoctoral Fellowship in Bioinformatics and Evolutionary Genomics


A postdoctoral training position is currently available in the Computational and Statistical Genomics Branch (CSGB) of the National Human Genome Research Institute (NHGRI). The position is located in the laboratory of Andy Baxevanis, Ph.D., whose research group uses comparative genomics approaches to better-understand the molecular innovations that drove the surge of diversity in early animal evolution. The overarching theme of Dr. Baxevanis’ research program is focused on how non-traditional animal models can be used to convey critical insights into human disease research, in line with the NIH Intramural Research Program’s renewed emphasis on developing new animal models for the study of basic biology.

With this translational context in mind, Dr. Baxevanis’ group is currently leading an international effort to sequence two cnidarian species: Hydractinia echinata and Hydractinia symbiolongicarpus. The regenerative abilities of these colonial hydrozoans make them excellent models for the study of key questions related to pluripotency, allorecognition, and stem cell biology, work that will be significantly advanced by the availability of high-quality whole-genome sequencing data from these organisms. In addition, and in collaboration with colleagues at the Whitney Marine Laboratory of the University of Florida, the group is also now focusing on polychaete species that show particular promise for advancing our understanding of regeneration and early developmental processes. The successful applicant will have the opportunity to develop and apply bioinformatic approaches to these and other large-scale genomic data sets, focusing on the evolution of specific protein families, with an emphasis on examining their putative roles in disease causation.

Candidates should have or be close to obtaining a Ph.D. or equivalent degree in bioinformatics, computational biology, computer science, molecular biology, or a closely related field. Candidates with a background in evolutionary biology are particularly encouraged to apply. Programming skills and experience in the application of computational methods to genomic data are highly desirable. Applicants must possess good communication skills and be fluent in both spoken and written English. The ability to learn how to use new software and quickly become expert in its use, critical thinking, problem-solving abilities, and the ability to work semi-independently are required.

The NIH Intramural Research Program is on the Bethesda, Maryland campus and offers a wide array of training opportunities for scientists early in their careers. The funding for this position is stable and offers the trainee wide latitude in the design and pursuit of their research project. The successful candidate will have access to NHGRI’s established and robust bioinformatics infrastructure, as well as a ‘Top 500’ high-performance computing resource made available through NIH’s Center for Information Technology (CIT).

Interested applicants should submit a curriculum vitae, a detailed letter of interest, and the names of three potential references to Dr. Baxevanis at andy@mail.nih.gov<mailto:andy@mail.nih.gov>.

For more information on CSGB and NHGRI’s Intramural Research Program, please see http://genome.gov/DIR/.


DHHS and NIH are Equal Opportunity Employers and encourage applications from
women and minorities.

 

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***POSTED 3/28/17***

Temp-to-hire Research Technician (EM Connectome Annotator)
Tracking Code
375-908
Job Description
The Janelia Research Campus of the Howard Hughes Medical Institute (Janelia) is using high-throughput electron microscopy (EM) to completely image multiple brains and nervous systems of the fruit fly, Drosophila melanogaster. Janelia scientists will utilize these massive data sets to reconstruct neuronal circuits, ultimately culminating in the complete connectome—or wiring diagram—of the fly brain. The connectome will provide the most complete anatomical description of a complex nervous system to date in an organism uniquely suited to combine this anatomical information with functional imaging, electrophysiology, quantitative behavioral assays, precise genetic manipulation of identified cell types and computational modeling. Thus we expect these circuit-level reconstructions to inform specific biological experiments, enabling dramatic leaps in our understanding of brain function.

We seek outstanding individuals to become full-time research technicians to contribute to our adult fly brain project. The research technician will be responsible for identifying, annotating, and analyzing neurons in a large digitized volume of serial electron microscopic images captured from an adult fly brain. Candidates will receive training in neurobiological concepts spanning neural ultrastructure to information processing while using custom software to annotate, generate 3-dimensional reconstructions of, and analyze functional neural networks.

Qualifications:
Ability to dedicate 40 hours a week
Some college-level training in cellular biology, neuroscience, biomedical engineering, or computer science required
Strong desire to understand the neural bases of higher order function
Ability to work independently yet assimilate well into a team
Proactive, resourceful, and able to generate results according to defined deadlines
Ability to mentally visualize complex, three dimensional structures
Ability to think at multiple levels of abstraction
Ability to work at a computer workstation, performing detailed, repetitive tasks
Good color vision required
Experience interpreting light and/or electron microscopic images a plus
Previous experience with Matlab, Python, or other programming languages a plus
Previous experience working with databases and/or interacting with software developers a plus

About Janelia
Janelia Research Campus is a pioneering research center in Ashburn, Virginia, where scientists pursue fundamental questions in neuroscience and imaging. The Howard Hughes Medical Institute (HHMI) launched Janelia in 2006, establishing an intellectually distinctive environment for scientists to do creative, collaborative, hands-on work. To learn more about working at Janelia, visit janelia.org/careers.

HHMI is an Equal Opportunity Employer.
Job Location
Ashburn, Virginia, United States
Position Type
Full-Time/Regular

To apply, click here.

***POSTED 3/23/17***

Research Fellow, Metagenomic Assembly

Dovetail is seeking one or more Research Fellows to develop and execute a research project in metagenomic genome assembly. The Research Fellow would coordinate with the Scientific Advisory Board of Dovetail Genomics and the Research and Development team to design and implement a research program using Dovetail’s proprietary approach to complete metagenomic assembly and annotation.

The idea candidate would have a Ph.D. in computational biology or a related life science or computer science discipline and research experience in the field of metagenomics assembly and analysis. The Research Fellow would have a semi-independent position with flexibility to direct his/her research project in line with broader company goals.

Key responsibilities:
• Design and implement an independent research project
• Work closely with Scientific Advisory Board and Dovetail Product Development team
• Communicate findings via scientific reports and scientific manuscripts
• Collaborate with experimental and computational groups at Dovetail for data generation and analysis

Desired Background and Skills includes:
• PhD in computational biology or a related life science or computer science discipline
• Excellent written and verbal communication skills
• Desire to drive high impact scientific discovery in an industry research setting
• Experience with experimental and computational metagenomic assembly and analysis methodology

Dovetail Genomics is an early stage Santa Cruz-based start-up company developing cutting-edge genomics technologies for vastly improving genome assembly, uncovering critical structural variation information, and many other exciting applications in genomics. We are a diverse, talented, multi-disciplinary team innovating in the field of genomics, with the ultimate goal of leaving a lasting impact on the world by providing researchers and clinicians with tools for better informing biological understanding.

To apply, send your personal CV to careers@dovetail-genomics.com. No phone calls please. 

***POSTED 3/3/17***

Biostatistician
Job Tracking ID: 512790-551946
Job Location: Alexandria, VA
Job Level: Any
Level of Education: Masters Degree
Job Type: Full-Time/Regular
Date Updated: February 07, 2017
Years of Experience: 7 - 10 Years
Starting Date: September 30, 2016

Job Description:
Karna is seeking immediate placement for a Biostatistician to provide high level expertise in applicable public health disciplines to collect, abstract, code, analyze, and interpret scientific data contained within information systems and databases related to public health for current work with the Defense Suicide Prevention Office within the Department of Defense. The Biostatistician will be responsible for statistical analysis and reporting of captured data. Applicant will be expected to consult on design of statistical analysis plans, perform high-level statistical processes and report findings to multiple constituencies.

Responsibilities include:
• Design, develop, and implement research methods and advanced data analytic techniques to analyze key questions related to suicide prevention program and intervention outcomes and effectiveness.
• Utilize knowledge of social science, epidemiology, and public health literature, theories, and methods.
• Combine large and small data sets to explore hypotheses and answer research questions.
• Ability to conduct descriptive and inferential statistics, including regression and analysis of variance.
• Provide consultation on design of data processing systems, specifying the needed output, the required input and the methods of validation and quality control.
• Responsible for ensuring the statistical validity of study activities by solving problems occurring in the data collection process.
• Provide guidance and instruction on appropriate statistical evaluation methods and practices.
• Assists clients in interpretation of statistical results.
• Clearly summarize findings in oral, written, and graphical forms.
• Performs data replication studies and critically evaluates statistical procedures used to produce study results.
• Work with team to recommend and administer effective statistical methodology and strategies necessary for the creation, completion, and analysis of epidemiology or research projects and supervises the planning and designing of analytical procedures by others.
• Provide technical expertise, consultation, advice on statistical analysis, methods and techniques for data studies. Collaborate with other researchers in the healthcare disciplines.
• Convert highly statistical numerical output results into easily-understood written form for display in PowerPoint slides, Word documents and Excel spreadsheets.
• Perform data mining exercises to identify areas of excellent performance and areas of potential improvement.
• Apply statistical methods including, but not limited to: linear, logistic, and conditional logistic regression models, as well as survey statistics and survival analysis.
• Perform a variety of tasks relying on extensive clinical, statistical and information technology experience and judgment to plan and accomplish goals.
• Prepare analysis plans and writes detailed specifications for analysis files, consistency checks, tables, and figures; communicate with clients regarding statistical analysis issues.

Experience and Skills:
Qualifications:
• Master’s degree or PhD preferred in Biostatistics, Computer Science, Statistical Mathematics, or other related field and/or discipline.
• 7-10 years’ experience as a Biostatistician using commercial statistical software packages, particularly SPSS.
• Experience with sample size calculations and methodologies.
• Knowledge of surveillance and case-control study design and analysis. Experience with a variety of different groups in various disciplines.
• Well-versed in Microsoft Office products.
• Knowledge of the principles, practices, and methods to plan and implement public health programs.
• Familiarity with DoD policies and procedures
• Strong database skills particularly querying and transforming datasets for import into various applications.
• Knowledge of various healthcare data sources and clinical issues.
• Excellent written and oral communication.
• Strong attention to detail and problem-solving abilities.

Other Requirements:
• U.S. Citizenship.
• Previous or current Public Trust or higher clearance. Able to obtain CAC or PIV ready status prior to reporting for work.

• Obtain/maintain a favorable FBI National Criminal History Check (fingerprint check), two forms of identity proofed identification (I-9 document), and submit a National Agency Check and Law Credit (NACLAC II) vetting package for processing.

• Maintain favorable FBI National Criminal History checks and ensure completion and successful adjudication of a NACLAC as required for Federal employment.

Founded in 2008 and headquartered in Atlanta, Karna is an SBA certified 8(a), economically disadvantaged woman-owned small business dedicated to: 'Improving health through transformational strategies, evidence-based approaches, and effective technologies'. We are focused on providing programmatic and information technology (IT) consulting services for various government agencies and private organizations.

APPLY HERE.

***POSTED 3/3/17***

Public Health Analyst
Job Tracking ID: 512790-561953
Job Location: Alexandria , VA
Job Level: Mid Career (2+ years)
Level of Education: BA/BS
Job Type: Full-Time/Regular
Date Updated: February 03, 2017
Years of Experience: 5 - 7 Years
Starting Date: January 30, 2017

Job Description:
Karna is seeking a Public Health Analyst for ongoing work with the Defense Suicide Prevention Office. The candidate will serve as the principal advisor. He or she will direct and oversee multi-functional program activities. The candidate will also provide substantive program consultation, guidance, and assistance and is responsible for carrying out and promoting significant public health program activities with relative independence.

Responsibilities include:

Serve as the principal representative for a well-defined and established program of moderate complexity.
Provide subject matter expertise and working knowledge of DoD and Federal laws and policies affecting personnel and health related data collections to ensure that its data acquisition efforts are in compliance with all regulatory guidance.
Provide substantive program consultation, guidance, and assistance and is responsible for carrying out and promoting significant public health program activities with relative independence.
Establish and maintain an integrated system of information gathering and reporting devices and analyzes the data and assesses the program needs in terms of strategies, services, and resources.
Conduct research activities (extensive literature reviews), collect, and analyze data to address highly complex program needs. Develop and/or recommend program intervention, prevention, and/or control strategies.
Prepare reports for use in evaluating program operations and the other work incidental to the development of information gathering system.
Perform duties related to the development, extension, and improvement of health care and/or communications.
Establish and/or apply evaluation criteria and standards for multiple programs to measure monitor and ensure standards of adequacy, legal and regulatory compliance requirements, and program effectiveness are met.
Independently, or as part of a team, carry out public health projects and/or programs. Design, develop, implement, manage and evaluate all aspects of a complex, politically sensitive, or developmental special project or program within an assigned area.
Provide high level advisory services to agencies and organizations in developing, extending, and/or improving health care systems, public health strategies, communications and services. Analyze existing or proposed activities.
Identify needs for improvement and methods and resources required to accomplish improvements.
Perform difficult and complex advisory and assistance functions. Provide comprehensive technical and administrative advice and assistance to an assigned domestic or international project or program.
Resolve difficult management and administrative problems that prevent effective program application.
Plan, implement, and present training systems for health practitioners, researchers, and other professionals; conducts and/or assists in the development and delivery of training courses (e.g., community planning, prevention and intervention, outreach strategies, data collection, etc.); and assist with special studies and/or demonstrations.
Experience and Skills:
Candidates must have a minimum of 5 years of specialized experience including oversight of public health programs.

BA/BS required, Master's preferred.
Experience in Suicidology or other behavioral health discipline.
Well-versed in Microsoft Office products, specifically in Excel and PowerPoint.
Proficient in the use of analysis software, namely SPSS.
Excellent written and oral communication.
Strong attention to detail and problem-solving abilities.
Ability to multi-task and re-prioritize to meet deadlines.
Other Requirements:

U.S. Citizenship.
Ability to obtain CAC or PIV ready status prior to reporting for work.
Obtain/maintain a favorable FBI National Criminal History Check (fingerprint check), two forms of identity proofed identification (I-9 document), and submit a National Agency Check and Law Credit (NACLAC II) vetting package for processing.
Maintain favorable FBI National Criminal History checks and ensure completion and successful adjudication of a NACLAC as required for Federal employment.
Founded in 2008 and headquartered in Atlanta, Karna is an SBA certified 8(a), economically disadvantaged woman-owned small business dedicated to: 'Improving health through transformational strategies, evidence-based approaches, and effective technologies'. We are focused on providing programmatic and information technology (IT) consulting services for various government agencies and private organizations.

APPLY HERE.