Crandall and Bendall Co-Author Article Published in Clinical and Experimental Dermatology

March 11, 2019

Keith Crandall (Director, Computational Biology Institute; Professor, Department of Epidemiology and Biostatistics) and Matthew Bendall (Graduate Research Assistant, Computational Biology Institute) co-authored an article, titled "Transcriptome Patterns in Hidradenitis Suppurativa: Support for the Role of Antimicrobial Peptides and Interferon Pathways in Disease Pathogenesis," published in Clinical and Experimental Dermatology on March 3rd, 2019.

Hidradenitis suppurativa (HS) is a recurrent inflammatory disease of the apocrine sweat glands. Immune dysregulation likely contributes to the pathogenesis of HS. The purpose of this study was to harness mRNA expression arrays to investigate the transcriptome profile in HS compared to control skin. The antimicrobial peptide Dermcidin and the cytokine regulator IL37 were both significantly downregulated in the HS specimens (Dermcidin expression log ratio -3.930, expression p-value 0.041; IL 37 expression log ratio -3.291, expression p-value 0.000547). Pathway analysis revealed the interferon-signaling pathway, leukocyte extravasation pathway, TH1 and TH2 pathways and nuclear factor of activated T-cells (NFAT) as the top-five upregulated pathways in the HS samples. Evaluation of transcriptome patterns in HS compared to normal skin demonstrated downregulation of the antimicrobial peptide dermcidin, and the innate immune regulator IL37, as well as upregulation of interferon pathways and pathways of leukocyte activation.